There has been little research into using cannabis as a way of mitigating the damage that can be caused by ecstasy/MDMA. Anecdotally, many use the two drugs together, often at the same time. This can confound the effects between the two, and there are likely to be both pros and cons to such usage.
How the two combine to affect serotonin and dopamine receptors, whether cannabis can help reduce any neurotoxicity or the negative effects that stimulants usually provide, and whether the two work together synergistically, all need to be looked at in more detail.
There is some interest in the therapeutic effects of low-to-moderate doses of MDMA, especially for depression and post-traumatic stress disorder (PTSD), due to its empathogenic-entactogenic and slight psychedelic effects. There is interest in psychedelic therapy for similar reasons.
Although overuse and high doses of MDMA in non-therapeutic contexts isn’t recommended, the way in which we target serotonin and other receptors in unique and long-term ways is perhaps a way to get something more safe & suitable than daily use of antidepressants and sedatives.
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